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Bayesian inference of kinetic schemes for ion channels by Kalman filtering

Inferring adequate kinetic schemes for ion channel gating from ensemble currents is a daunting task due to limited information in the data. We address this problem by using a parallelized Bayesian filter to specify hidden Markov models for current and fluorescence data. We demonstrate the flexibilit...

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Detalles Bibliográficos
Autores principales: Münch, Jan L, Paul, Fabian, Schmauder, Ralf, Benndorf, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342998/
https://www.ncbi.nlm.nih.gov/pubmed/35506659
http://dx.doi.org/10.7554/eLife.62714