Proteome-Wide Profiling of the Covalent-Druggable Cysteines with a Structure-Based Deep Graph Learning Network

Covalent ligands have attracted increasing attention due to their unique advantages, such as long residence time, high selectivity, and strong binding affinity. They also show promise for targets where previous efforts to identify noncovalent small molecule inhibitors have failed. However, our limit...

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Detalles Bibliográficos
Autores principales: Du, Hongyan, Jiang, Dejun, Gao, Junbo, Zhang, Xujun, Jiang, Lingxiao, Zeng, Yundian, Wu, Zhenxing, Shen, Chao, Xu, Lei, Cao, Dongsheng, Hou, Tingjun, Pan, Peichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAAS 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343084/
https://www.ncbi.nlm.nih.gov/pubmed/35958111
http://dx.doi.org/10.34133/2022/9873564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343084/
https://www.ncbi.nlm.nih.gov/pubmed/35958111
http://dx.doi.org/10.34133/2022/9873564

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