Regulation of proton partitioning in kinase-activating acute myeloid leukemia and its therapeutic implication

Gain-of-function kinase mutations are common in AML and usually portend an inferior prognosis. We reported a novel mechanism whereby kinase mutants induced intracellular alkalization characteristic in oncogenesis. Thirteen kinases were found to activate sodium/hydrogen exchanger (NHE1) in normal hem...

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Detalles Bibliográficos
Autores principales: Man, Cheuk-Him, Zeng, Xiaoyuan, Lam, Wing, Ng, Timothy C. C., Kwok, Tsz-Ho, Dang, Kenny C. C., Leung, Thomas W. Y., Ng, Nelson K. L., Lam, Stephen S. Y., Cher, Chae-Yin, Leung, Anskar Y. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343251/
https://www.ncbi.nlm.nih.gov/pubmed/35624145
http://dx.doi.org/10.1038/s41375-022-01606-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343251/
https://www.ncbi.nlm.nih.gov/pubmed/35624145
http://dx.doi.org/10.1038/s41375-022-01606-0

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