Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

During the early stages of Alzheimer’s disease (AD) in both mouse models and human patients, soluble forms of Amyloid-β 1–42 oligomers (Aβ42o) trigger loss of excitatory synapses (synaptotoxicity) in cortical and hippocampal pyramidal neurons (PNs) prior to the formation of insoluble amyloid plaques...

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Detalles Bibliográficos
Autores principales: Lee, Annie, Kondapalli, Chandana, Virga, Daniel M., Lewis, Tommy L., Koo, So Yeon, Ashok, Archana, Mairet-Coello, Georges, Herzig, Sebastien, Foretz, Marc, Viollet, Benoit, Shaw, Reuben, Sproul, Andrew, Polleux, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343354/
https://www.ncbi.nlm.nih.gov/pubmed/35915085
http://dx.doi.org/10.1038/s41467-022-32130-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343354/
https://www.ncbi.nlm.nih.gov/pubmed/35915085
http://dx.doi.org/10.1038/s41467-022-32130-5

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