Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis

Ferroptosis, a type of regulated cell death brought about by lipid peroxidation, has been discovered to suppress tumor growth. Here, we report that targeting RRM1 promotes ferroptosis and affects sensitivity to radiation and chemotherapeutics in cancer cells. In vitro experiments demonstrate that RR...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Chen, Bin, Wang, Ruru, Xu, An, Wu, Lijun, Lu, Huayi, Zhao, Guoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343379/
https://www.ncbi.nlm.nih.gov/pubmed/35915092
http://dx.doi.org/10.1038/s41420-022-01140-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343379/
https://www.ncbi.nlm.nih.gov/pubmed/35915092
http://dx.doi.org/10.1038/s41420-022-01140-z

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