D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

The D-aspartate oxidase (DDO) gene encodes the enzyme responsible for the catabolism of D-aspartate, an atypical amino acid enriched in the mammalian brain and acting as an endogenous NMDA receptor agonist. Considering the key role of NMDA receptors in neurodevelopmental disorders, recent findings s...

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Detalles Bibliográficos
Autores principales: Lombardo, Barbara, Pagani, Marco, De Rosa, Arianna, Nunziato, Marcella, Migliarini, Sara, Garofalo, Martina, Terrile, Marta, D’Argenio, Valeria, Galbusera, Alberto, Nuzzo, Tommaso, Ranieri, Annaluisa, Vitale, Andrea, Leggiero, Eleonora, Di Maio, Anna, Barsotti, Noemi, Borello, Ugo, Napolitano, Francesco, Mandarino, Alessandra, Carotenuto, Marco, Heresco-Levy, Uriel, Pasqualetti, Massimo, Malatesta, Paolo, Gozzi, Alessandro, Errico, Francesco, Salvatore, Francesco, Pastore, Lucio, Usiello, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343392/
https://www.ncbi.nlm.nih.gov/pubmed/35915065
http://dx.doi.org/10.1038/s41398-022-02088-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343392/
https://www.ncbi.nlm.nih.gov/pubmed/35915065
http://dx.doi.org/10.1038/s41398-022-02088-5

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