Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to chemotherapeutics by impairing lysosomal function

Despite novel therapy regimens and extensive research, chemoresistance remains a challenge in leukemia treatment. Of note, recent studies revealed lysosomes as regulators of cell death and chemotherapy response, suggesting this organelle is a novel target for chemosensitization. Interestingly, drug-...

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Detalles Bibliográficos
Autores principales: Geisslinger, Franz, Müller, Martin, Chao, Yu-Kai, Grimm, Christian, Vollmar, Angelika M., Bartel, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343397/
https://www.ncbi.nlm.nih.gov/pubmed/35915060
http://dx.doi.org/10.1038/s41419-022-05105-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343397/
https://www.ncbi.nlm.nih.gov/pubmed/35915060
http://dx.doi.org/10.1038/s41419-022-05105-z

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