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PfSPZ-CVac malaria vaccine demonstrates safety among malaria-experienced adults: A randomized, controlled phase 1 trial

BACKGROUND: Plasmodium falciparum (Pf) Sporozoite (SPZ) Chemoprophylaxis Vaccine (PfSPZ-CVac) involves concurrently administering infectious PfSPZ and malaria drug, often chloroquine (CQ), to kill liver-emerging parasites. PfSPZ-CVac (CQ) protected 100% of malaria-naïve participants against controll...

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Detalles Bibliográficos
Autores principales: Coulibaly, Drissa, Kone, Abdoulaye K., Traore, Karim, Niangaly, Amadou, Kouriba, Bourema, Arama, Charles, Zeguime, Amatigue, Dolo, Amagana, Lyke, Kirsten E., Plowe, Christopher V., Abebe, Yonas, Potter, Gail E., Kennedy, Jessie K., Galbiati, Shirley M., Nomicos, Effie, Deye, Gregory A., Richie, Thomas L., James, Eric R., KC, Natasha, Sim, B. Kim Lee, Hoffman, Stephen L., Doumbo, Ogobara K., Thera, Mahamadou A., Laurens, Matthew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343417/
https://www.ncbi.nlm.nih.gov/pubmed/35928033
http://dx.doi.org/10.1016/j.eclinm.2022.101579