Plasmid-mediated gene transfer of Cas9 induces vector-related but not SpCas9-related immune responses in human retinal pigment epithelial cells

The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein 9 (Cas9) system represents a powerful gene-editing tool and could enable treatment of blinding diseases of the retina. As a peptide of bacterial origin, we investigated the immunogenic potential of Cas9 in model...

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Detalles Bibliográficos
Autores principales: Pfromm, Julia K., Bonillo, Mario, Dauletbekov, Daniyar, Bucher, Kirsten, Fischer, M. Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343442/
https://www.ncbi.nlm.nih.gov/pubmed/35915300
http://dx.doi.org/10.1038/s41598-022-17269-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343442/
https://www.ncbi.nlm.nih.gov/pubmed/35915300
http://dx.doi.org/10.1038/s41598-022-17269-x

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