Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic temporal lobe epilepsy (TLE), and interneuron grafting into the epileptic hippocampus reduces SRS and improves cognitive function. This study investigated whether graft-derived gamma-aminobutyric acid positiv...

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Detalles Bibliográficos
Autores principales: Upadhya, Dinesh, Attaluri, Sahithi, Liu, Yan, Hattiangady, Bharathi, Castro, Olagide W., Shuai, Bing, Dong, Yi, Zhang, Su-Chun, Shetty, Ashok K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343458/
https://www.ncbi.nlm.nih.gov/pubmed/35915118
http://dx.doi.org/10.1038/s41536-022-00234-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343458/
https://www.ncbi.nlm.nih.gov/pubmed/35915118
http://dx.doi.org/10.1038/s41536-022-00234-7

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