Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons

Huntington’s disease (HD) is a monogenic disease that results in a combination of motor, psychiatric, and cognitive symptoms. It is caused by a CAG trinucleotide repeat expansion in the exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant HTT protein (mHTT) with an extend...

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Detalles Bibliográficos
Autores principales: Dinamarca, Margarita C., Colombo, Laura, Tousiaki, Natalia E., Müller, Matthias, Pecho-Vrieseling, Eline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343803/
https://www.ncbi.nlm.nih.gov/pubmed/35928225
http://dx.doi.org/10.3389/fmolb.2022.916019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343803/
https://www.ncbi.nlm.nih.gov/pubmed/35928225
http://dx.doi.org/10.3389/fmolb.2022.916019

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