Cargando…
Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons
Huntington’s disease (HD) is a monogenic disease that results in a combination of motor, psychiatric, and cognitive symptoms. It is caused by a CAG trinucleotide repeat expansion in the exon 1 of the huntingtin (HTT) gene, which results in the production of a mutant HTT protein (mHTT) with an extend...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343803/ https://www.ncbi.nlm.nih.gov/pubmed/35928225 http://dx.doi.org/10.3389/fmolb.2022.916019 |