Cargando…

Single-Cell Transcriptomics Reveals Killing Mechanisms of Antitumor Cytotoxic CD4(+) TCR-T Cells

T cell receptor-engineered T cells (TCR-Ts) have emerged as potent cancer immunotherapies. While most research focused on classical cytotoxic CD8(+) T cells, the application of CD4(+) T cells in adoptive T cell therapy has gained much interest recently. However, the cytotoxic mechanisms of CD4(+) TC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Yanling, Xu, Qumiao, Liu, Songming, Li, Jie, Wang, Fei, Li, Ziyi, Liao, Lijuan, Lu, Yuting, Li, Yijian, Mu, Feng, Sun, Hai-Xi, Zhu, Linnan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9343810/ https://www.ncbi.nlm.nih.gov/pubmed/35928827 http://dx.doi.org/10.3389/fimmu.2022.939940

Ejemplares similares

Single-cell transcriptome analysis of the heterogeneous effects of differential expression of tumor PD-L1 on responding TCR-T cells
por: Ding, Renpeng, et al.
Publicado: (2021)

A single-cell approach to engineer CD8+ T cells targeting cytomegalovirus
por: Wang, Fei, et al.
Publicado: (2020)

NK cells specifically TCR-dressed to kill cancer cells
por: Mensali, Nadia, et al.
Publicado: (2019)

Potentiating the Antitumor Activity of Cytotoxic T Cells via the Transmembrane Domain of IGSF4 That Increases TCR Avidity
por: Kim, Hye-Ran, et al.
Publicado: (2021)

Autophagic flux restoration of senescent T cells improves antitumor activity of TCR‐engineered T cells
por: Zhang, Chaoting, et al.
Publicado: (2022)

The Quest for the Best: How TCR Affinity, Avidity, and Functional Avidity Affect TCR-Engineered T-Cell Antitumor Responses
por: Campillo-Davo, Diana, et al.
Publicado: (2020)

TCR-Engineered, Customized, Antitumor T Cells for Cancer Immunotherapy: Advantages and Limitations
por: Chhabra, Arvind
Publicado: (2011)

Therapeutic potential of CRISPR/Cas9 gene editing in engineered T‐cell therapy
por: Gao, Qianqian, et al.
Publicado: (2019)

Single-cell transcriptomics identifies multiple pathways underlying antitumor function of TCR- and CD8αβ-engineered human CD4(+) T cells
por: Rath, Jan A., et al.
Publicado: (2020)

Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets
por: Laletin, Vladimir, et al.
Publicado: (2023)

Decreased cytotoxic T cells and TCR clonality in organ transplant recipients with squamous cell carcinoma
por: Frazzette, Nicholas, et al.
Publicado: (2020)

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros
por: Winandy, Susan, et al.
Publicado: (1999)

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
por: Xu, Yiyang, et al.
Publicado: (2018)

TCR/CD3 coupling to Fas-based cytotoxicity
Publicado: (1995)

Single-cell transcriptome and TCR profiling reveal activated and expanded T cell populations in Parkinson’s disease
por: Wang, Pingping, et al.
Publicado: (2021)

Tumor-Activated TCRγ δ (+) T Cells from Gastric Cancer Patients Induce the Antitumor Immune Response of TCRα β (+) T Cells via Their Antigen-Presenting Cell-Like Effects
por: Mao, Chaoming, et al.
Publicado: (2014)

The Kinematics of Cytotoxic Lymphocytes Influence Their Ability to Kill Target Cells
por: Bhat, Purnima, et al.
Publicado: (2014)

Clonal deletion of postthymic T cells: veto cells kill precursor cytotoxic T lymphocytes
Publicado: (1992)

Glioma Stemlike Cells Enhance the Killing of Glioma Differentiated Cells by Cytotoxic Lymphocytes
por: Bassoy, Esen Yonca, et al.
Publicado: (2016)

Potent Antitumor Activity Generated by a Novel Tumor Specific Cytotoxic T Cell
por: Wang, Zheng, et al.
Publicado: (2013)

Decreased Treg Cell and TCR Expansion Are Involved in Long-Lasting Graves’ Disease
por: Chen, Ziyi, et al.
Publicado: (2021)

NY-ESO-1 specific TCR engineered T-cells mediate sustained antigen-specific antitumor effects in myeloma
por: Rapoport, Aaron P., et al.
Publicado: (2015)

Protection of Hepatocytes from Cytotoxic T Cell Mediated Killing by Interferon-Alpha
por: Willberg, Christian B., et al.
Publicado: (2007)

Cyclooxygenase 2 Modulates Killing of Cytotoxic T Lymphocytes by Colon Cancer Cells
por: Wang, Quanxin, et al.
Publicado: (2009)

Correction: The Kinematics of Cytotoxic Lymphocytes Influence Their Ability to Kill Target Cells
Publicado: (2014)

Less cholesterol means better tumor killing for cytotoxic T9 cells
por: Griesenauer, Brad, et al.
Publicado: (2018)

Supramolecular attack particle: the way cytotoxic T lymphocytes kill target cells
por: Liu, Jiaqi, et al.
Publicado: (2020)

ImmTACs: bi-specific TCR-anti-CD3 fusions for targeted tumour killing
por: Donnellan, Zoe, et al.
Publicado: (2015)

TCR engineered T cells for solid tumor immunotherapy
por: Zhang, Yikai, et al.
Publicado: (2022)

Single-Cell TCR and Transcriptome Analysis: An Indispensable Tool for Studying T-Cell Biology and Cancer Immunotherapy
por: Pasetto, Anna, et al.
Publicado: (2021)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity
por: Halle, Stephan, et al.
Publicado: (2016)

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire
Publicado: (1994)

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2
por: Shimizu, Kanako, et al.
Publicado: (2021)

Potentiating CD8(+) T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling
por: Yuan, Juanjuan, et al.
Publicado: (2021)

TCR Signaling in T Cell Memory
por: Daniels, Mark A., et al.
Publicado: (2015)

Trilineage Sequencing Reveals Complex TCRβ Transcriptomes in Neutrophils and Monocytes Alongside T Cells
por: Fuchs, Tina, et al.
Publicado: (2021)

DGKα/ζ inhibition lowers the TCR affinity threshold and potentiates antitumor immunity
por: Kureshi, Rakeeb, et al.
Publicado: (2023)

Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response
por: Ueda, Norihiro, et al.
Publicado: (2018)

Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells
por: Yang, Juhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m8vm7f3qdfrmu0kpa5qhk10n2n