AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer

BACKGROUND: Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has the most aggressive clinical course amongst pulmonary tumors. Whereas cancers that acquire a mutation/copy gain in PIK3CA or loss of PTEN have been i...

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Detalles Bibliográficos
Autores principales: Hung, Ming-Chun, Wang, Wan-Ping, Chi, Ya-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344631/
https://www.ncbi.nlm.nih.gov/pubmed/35918763
http://dx.doi.org/10.1186/s13578-022-00862-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344631/
https://www.ncbi.nlm.nih.gov/pubmed/35918763
http://dx.doi.org/10.1186/s13578-022-00862-y

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