Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome

Periplocymarin (PPM), a cardiac glycoside isolated from Cortex periplocae, has a strong anti-tumor effect against various cancer cells. However, cardiotoxicity and rapid metabolism hinder its clinical applications. In this study, small molecule prodrug was integrated into PEGylated liposome to impro...

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Detalles Bibliográficos
Autores principales: Zhang, Huiyun, Wei, Shunru, Zhang, Yu, Pan, Anran, Adu-Frimpong, Michael, Sun, Congyong, Qi, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344961/
https://www.ncbi.nlm.nih.gov/pubmed/35912819
http://dx.doi.org/10.1080/10717544.2022.2104406

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344961/
https://www.ncbi.nlm.nih.gov/pubmed/35912819
http://dx.doi.org/10.1080/10717544.2022.2104406

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