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Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome
Periplocymarin (PPM), a cardiac glycoside isolated from Cortex periplocae, has a strong anti-tumor effect against various cancer cells. However, cardiotoxicity and rapid metabolism hinder its clinical applications. In this study, small molecule prodrug was integrated into PEGylated liposome to impro...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344961/ https://www.ncbi.nlm.nih.gov/pubmed/35912819 http://dx.doi.org/10.1080/10717544.2022.2104406 |