Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export

Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration and an important therapeutic target. Our current understanding of TDP-43 nucleocytoplasmic transport does not fully explain its predominantly nuclear localization or mislocalization in disease. Here, we show that...

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Detalles Bibliográficos
Autores principales: Duan, Lauren, Zaepfel, Benjamin L., Aksenova, Vasilisa, Dasso, Mary, Rothstein, Jeffrey D., Kalab, Petr, Hayes, Lindsey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345261/
https://www.ncbi.nlm.nih.gov/pubmed/35858577
http://dx.doi.org/10.1016/j.celrep.2022.111106

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345261/
https://www.ncbi.nlm.nih.gov/pubmed/35858577
http://dx.doi.org/10.1016/j.celrep.2022.111106

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