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Nuclear RNA binding regulates TDP-43 nuclear localization and passive nuclear export
Nuclear clearance of the RNA-binding protein TDP-43 is a hallmark of neurodegeneration and an important therapeutic target. Our current understanding of TDP-43 nucleocytoplasmic transport does not fully explain its predominantly nuclear localization or mislocalization in disease. Here, we show that...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345261/ https://www.ncbi.nlm.nih.gov/pubmed/35858577 http://dx.doi.org/10.1016/j.celrep.2022.111106 |