Protein DEK and DTA Aptamers: Insight Into the Interaction Mechanisms and the Computational Aptamer Design

By blocking the DEK protein, DEK-targeted aptamers (DTAs) can reduce the formation of neutrophil extracellular traps (NETs) to reveal a strong anti-inflammatory efficacy in rheumatoid arthritis. However, the poor stability of DTA has greatly limited its clinical application. Thus, in order to design...

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Detalles Bibliográficos
Autores principales: Dai, Lijun, Zhang, Jiangnan, Wang, Xiaonan, Yang, Xiaoyue, Pan, Feng, Yang, Longhua, Zhao, Yongxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345330/
https://www.ncbi.nlm.nih.gov/pubmed/35928230
http://dx.doi.org/10.3389/fmolb.2022.946480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345330/
https://www.ncbi.nlm.nih.gov/pubmed/35928230
http://dx.doi.org/10.3389/fmolb.2022.946480

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