MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks

Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs). Recruitment to sites of damage is insufficient for ATR activation as one of two known ATR activators, either topoisom...

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Detalles Bibliográficos
Autores principales: Montales, Katrina, Ruis, Kenna, Lindsay, Howard, Michael, W. Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345342/
https://www.ncbi.nlm.nih.gov/pubmed/35917319
http://dx.doi.org/10.1371/journal.pone.0271905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345342/
https://www.ncbi.nlm.nih.gov/pubmed/35917319
http://dx.doi.org/10.1371/journal.pone.0271905

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