Cargando…

MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks

Ataxia Telangiectasia mutated and RAD3-related (ATR) kinase is activated by DNA replication stress and also by various forms of DNA damage, including DNA double-strand breaks (DSBs). Recruitment to sites of damage is insufficient for ATR activation as one of two known ATR activators, either topoisom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Montales, Katrina, Ruis, Kenna, Lindsay, Howard, Michael, W. Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345342/ https://www.ncbi.nlm.nih.gov/pubmed/35917319 http://dx.doi.org/10.1371/journal.pone.0271905

Ejemplares similares

Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks
por: Ruis, Kenna, et al.
Publicado: (2022)

Structure-function analysis of TOPBP1’s role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system
por: Montales, Katrina, et al.
Publicado: (2021)

hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
por: Richard, Derek J., et al.
Publicado: (2011)

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
por: Helmink, Beth A., et al.
Publicado: (2009)

NBN Phosphorylation regulates the accumulation of MRN and ATM at sites of DNA Double-Strand Breaks
por: Wen, Jie, et al.
Publicado: (2012)

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
por: Cheng, Qiao, et al.
Publicado: (2011)

Pre‐rRNA Facilitates TopBP1‐Mediated DNA Double‐Strand Break Response
por: Xin, Di, et al.
Publicado: (2023)

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
por: Richard, Derek J., et al.
Publicado: (2011)

Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks
por: Tisi, Renata, et al.
Publicado: (2020)

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1
por: Quennet, Verena, et al.
Publicado: (2011)

Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation
por: Mooser, Clémence, et al.
Publicado: (2020)

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
por: Langerak, Petra, et al.
Publicado: (2011)

Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae
por: Moore, Destaye M., et al.
Publicado: (2009)

Cell cycle-dependent resolution of DNA double-strand breaks
por: Ambrosio, Susanna, et al.
Publicado: (2015)

Transcription-dependent DNA double-strand breaks and human disease
por: Cristini, Agnese, et al.
Publicado: (2020)

MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways
por: Tripathi, Vivek, et al.
Publicado: (2018)

DNA Double Strand Breaks Occur Independent of AID in Hypermutating Ig Genes
por: Bross, Linda, et al.
Publicado: (2003)

Replication-Independent Endogenous DNA Double-Strand Breaks in Saccharomyces cerevisiae Model
por: Thongsroy, Jirapan, et al.
Publicado: (2013)

Double-strand break toxicity is chromatin context independent
por: Friskes, Anoek, et al.
Publicado: (2022)

Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection
por: Scherzer, Martin, et al.
Publicado: (2022)

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
por: Van Meter, Michael, et al.
Publicado: (2016)

Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break
por: Lou, Jieqiong, et al.
Publicado: (2020)

RNA polymerase II is recruited to DNA double-strand breaks for dilncRNA transcription in Drosophila
por: Böttcher, Romy, et al.
Publicado: (2021)

RAP80 phase separation at DNA double-strand break promotes BRCA1 recruitment
por: Qin, Caolitao, et al.
Publicado: (2023)

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
por: Westmoreland, James W., et al.
Publicado: (2013)

Excess Single-Stranded DNA Inhibits Meiotic Double-Strand Break Repair
por: Johnson, Rebecca, et al.
Publicado: (2007)

The ubiquitin landscape at DNA double-strand breaks
por: Messick, Troy E., et al.
Publicado: (2009)

Nucleolar responses to DNA double-strand breaks
por: Larsen, Dorthe Helena, et al.
Publicado: (2016)

Repair of DNA Double-Strand Breaks in Heterochromatin
por: Watts, Felicity Z.
Publicado: (2016)

Physiological Roles of DNA Double-Strand Breaks
por: Khan, Farhaan A., et al.
Publicado: (2017)

Boon and Bane of DNA Double-Strand Breaks
por: Schubert, Ingo
Publicado: (2021)

Replication independent DNA double-strand break retention may prevent genomic instability
por: Kongruttanachok, Narisorn, et al.
Publicado: (2010)

FANCJ helicase promotes DNA end resection by facilitating CtIP recruitment to DNA double-strand breaks
por: Nath, Sarmi, et al.
Publicado: (2020)

Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination
por: Gao, Min, et al.
Publicado: (2014)

Polo-like kinase 1 mediates BRCA1 phosphorylation and recruitment at DNA double-strand breaks
por: Chabalier-Taste, Corinne, et al.
Publicado: (2016)

An Adaptive Role for DNA Double-Strand Breaks in Hippocampus-Dependent Learning and Memory
por: Weber Boutros, Sydney, et al.
Publicado: (2022)

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks
por: Yan, Shan, et al.
Publicado: (2009)

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining
por: Cabrini, Matteo, et al.
Publicado: (2021)

Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1
por: Day, Matthew, et al.
Publicado: (2021)

Removal of heat-sensitive clustered damaged DNA sites is independent of double-strand break repair
por: Abramenkovs, Andris, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rj66m2kgabv216n2aqtc5f5623