The matricellular protein CCN5 induces apoptosis in myofibroblasts through SMAD7-mediated inhibition of NFκB

We previously showed that the matricellular protein CCN5 reverses established cardiac fibrosis (CF) through inducing apoptosis in myofibroblasts (MyoFBs) but not in cardiomyocytes or fibroblasts (FBs). In this study, we set out to elucidate the molecular mechanisms underlying CCN5-mediated selective...

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Detalles Bibliográficos
Autores principales: Nguyen, Mai Tuyet, Lee, Min-Ah, Kim, Young-Kook, Kook, Hyun, Jeong, Dongtak, Jang, Seung Pil, Kwak, Tae Hwan, Park, Woo Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345366/
https://www.ncbi.nlm.nih.gov/pubmed/35917315
http://dx.doi.org/10.1371/journal.pone.0269735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345366/
https://www.ncbi.nlm.nih.gov/pubmed/35917315
http://dx.doi.org/10.1371/journal.pone.0269735

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