The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways

Type 1 interferons (IFN-1) are pleiotropic cytokines with well-established anticancer and antiviral properties, particularly in mucosal tissues. Hence, natural IFN-1-inducing treatments are highly sought after in the clinic. Here, we report for the first time that cryptolepine, a pharmacoactive alka...

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Detalles Bibliográficos
Autores principales: Domfeh, Seth A., Narkwa, Patrick W., Quaye, Osbourne, Kusi, Kwadwo A., Addy, Bright S., Lant, Sian, Sumner, Rebecca P., Maluquer de Motes, Carlos, Awandare, Gordon A., Ansah, Charles, Mutocheluh, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345703/
https://www.ncbi.nlm.nih.gov/pubmed/35928633
http://dx.doi.org/10.1155/2022/8873536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345703/
https://www.ncbi.nlm.nih.gov/pubmed/35928633
http://dx.doi.org/10.1155/2022/8873536

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