Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A. HNF1A-deficient β-cells display impaired basal and glucose stimulated-insulin sec...

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Detalles Bibliográficos
Autores principales: González, Bryan J., Zhao, Haoquan, Niu, Jacqueline, Williams, Damian J., Lee, Jaeyop, Goulbourne, Chris N., Xing, Yuan, Wang, Yong, Oberholzer, Jose, Blumenkrantz, Maria H., Chen, Xiaojuan, LeDuc, Charles A., Chung, Wendy K., Colecraft, Henry M., Gromada, Jesper, Shen, Yufeng, Goland, Robin S., Leibel, Rudolph L., Egli, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345898/
https://www.ncbi.nlm.nih.gov/pubmed/35918471
http://dx.doi.org/10.1038/s42003-022-03696-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345898/
https://www.ncbi.nlm.nih.gov/pubmed/35918471
http://dx.doi.org/10.1038/s42003-022-03696-z

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