Transcriptomic diversity in human medullary thymic epithelial cells

The induction of central T cell tolerance in the thymus depends on the presentation of peripheral self-epitopes by medullary thymic epithelial cells (mTECs). This promiscuous gene expression (pGE) drives mTEC transcriptomic diversity, with non-canonical transcript initiation, alternative splicing, a...

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Detalles Bibliográficos
Autores principales: Carter, Jason A., Strömich, Léonie, Peacey, Matthew, Chapin, Sarah R., Velten, Lars, Steinmetz, Lars M., Brors, Benedikt, Pinto, Sheena, Meyer, Hannah V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345899/
https://www.ncbi.nlm.nih.gov/pubmed/35918316
http://dx.doi.org/10.1038/s41467-022-31750-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345899/
https://www.ncbi.nlm.nih.gov/pubmed/35918316
http://dx.doi.org/10.1038/s41467-022-31750-1

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