ERK1/2 inhibits Cullin 3/SPOP-mediated PrLZ ubiquitination and degradation to modulate prostate cancer progression

The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in prostate cancer (PCa), but how SPOP functions as a tumor suppressor and contributes to PCa pathogenesis remains poorly understood. Prostate Leucine Zipper (PrLZ) serves as a prostate-specific and androg...

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Detalles Bibliográficos
Autores principales: Fan, Yizeng, Hou, Tao, Dan, Weichao, Zhu, Yasheng, Liu, Bo, Wei, Yi, Wang, Zixi, Gao, Yang, Zeng, Jin, Li, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345960/
https://www.ncbi.nlm.nih.gov/pubmed/35194188
http://dx.doi.org/10.1038/s41418-022-00951-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345960/
https://www.ncbi.nlm.nih.gov/pubmed/35194188
http://dx.doi.org/10.1038/s41418-022-00951-y

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