Multiplex base editing to convert TAG into TAA codons in the human genome

Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment and viral resistance in bacteria. Here we take the first steps to extend this to human cells demonstrating exceptional base editing to convert TAG to TAA for 33 essential genes via a single transfection, and exami...

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Detalles Bibliográficos
Autores principales: Chen, Yuting, Hysolli, Eriona, Chen, Anlu, Casper, Stephen, Liu, Songlei, Yang, Kevin, Liu, Chenli, Church, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345975/
https://www.ncbi.nlm.nih.gov/pubmed/35918324
http://dx.doi.org/10.1038/s41467-022-31927-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345975/
https://www.ncbi.nlm.nih.gov/pubmed/35918324
http://dx.doi.org/10.1038/s41467-022-31927-8

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