Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia

Heme is an erythrocyte-derived toxin that drives disease progression in hemolytic anemias, such as sickle cell disease. During hemolysis, specialized bone marrow-derived macrophages with a high heme-metabolism capacity orchestrate disease adaptation by removing damaged erythrocytes and heme-protein...

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Detalles Bibliográficos
Autores principales: Vallelian, Florence, Buzzi, Raphael M., Pfefferlé, Marc, Yalamanoglu, Ayla, Dubach, Irina L., Wassmer, Andreas, Gentinetta, Thomas, Hansen, Kerstin, Humar, Rok, Schulthess, Nadja, Schaer, Christian A., Schaer, Dominik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345992/
https://www.ncbi.nlm.nih.gov/pubmed/35031770
http://dx.doi.org/10.1038/s41418-022-00932-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9345992/
https://www.ncbi.nlm.nih.gov/pubmed/35031770
http://dx.doi.org/10.1038/s41418-022-00932-1

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