SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remains poorly characterized despite enrichment of mutations in this region across variants of concern (VOCs). Here, we examine the contribution of the NTD to infection and cell-cell fusion by constructing...

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Detalles Bibliográficos
Autores principales: Meng, Bo, Datir, Rawlings, Choi, Jinwook, Bradley, John R., Smith, Kenneth G.C., Lee, Joo Hyeon, Gupta, Ravindra K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346021/
https://www.ncbi.nlm.nih.gov/pubmed/35963244
http://dx.doi.org/10.1016/j.celrep.2022.111220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346021/
https://www.ncbi.nlm.nih.gov/pubmed/35963244
http://dx.doi.org/10.1016/j.celrep.2022.111220

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