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SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike N-terminal domain (NTD) remains poorly characterized despite enrichment of mutations in this region across variants of concern (VOCs). Here, we examine the contribution of the NTD to infection and cell-cell fusion by constructing...

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Detalles Bibliográficos
Autores principales:	Meng, Bo, Datir, Rawlings, Choi, Jinwook, Bradley, John R., Smith, Kenneth G.C., Lee, Joo Hyeon, Gupta, Ravindra K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346021/ https://www.ncbi.nlm.nih.gov/pubmed/35963244 http://dx.doi.org/10.1016/j.celrep.2022.111220

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