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Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes

Heat shock protein 70 (Hsp70) is a molecular chaperone and central regulator of protein homeostasis (proteostasis). Paramount to this role is Hsp70’s binding to client proteins and co-chaperones to produce distinct complexes, such that understanding the protein–protein interactions (PPIs) of Hsp70 i...

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Detalles Bibliográficos
Autores principales: Johnson, Oleta T., Gestwicki, Jason E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346034/
https://www.ncbi.nlm.nih.gov/pubmed/35670950
http://dx.doi.org/10.1007/s12192-022-01281-1