Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic

BACKGROUND: BET inhibitors have been tested in several clinical trials where, despite encouraging preclinical results, substantial clinical benefit in monotherapy remains limited. This work illustrates the translational challenges and reports new data around the novel BET inhibitor, BI 894999. At cl...

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Detalles Bibliográficos
Autores principales: Tontsch-Grunt, Ulrike, Traexler, Paula-Elena, Baum, Anke, Musa, Hanny, Marzin, Kristell, Wang, Shaonan, Trapani, Francesca, Engelhardt, Harald, Solca, Flavio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346113/
https://www.ncbi.nlm.nih.gov/pubmed/35444289
http://dx.doi.org/10.1038/s41416-022-01815-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346113/
https://www.ncbi.nlm.nih.gov/pubmed/35444289
http://dx.doi.org/10.1038/s41416-022-01815-5

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