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Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic
BACKGROUND: BET inhibitors have been tested in several clinical trials where, despite encouraging preclinical results, substantial clinical benefit in monotherapy remains limited. This work illustrates the translational challenges and reports new data around the novel BET inhibitor, BI 894999. At cl...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346113/ https://www.ncbi.nlm.nih.gov/pubmed/35444289 http://dx.doi.org/10.1038/s41416-022-01815-5 |