Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity

The benefit of molecularly-informed therapies in cancer of unknown primary (CUP) is unclear. Here, we use comprehensive molecular characterization by whole genome/exome, transcriptome and methylome analysis in 70 CUP patients to reveal substantial mutational heterogeneity with TP53, MUC16, KRAS, LRP...

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Detalles Bibliográficos
Autores principales: Möhrmann, Lino, Werner, Maximilian, Oleś, Małgorzata, Mock, Andreas, Uhrig, Sebastian, Jahn, Arne, Kreutzfeldt, Simon, Fröhlich, Martina, Hutter, Barbara, Paramasivam, Nagarajan, Richter, Daniela, Beck, Katja, Winter, Ulrike, Pfütze, Katrin, Heilig, Christoph E., Teleanu, Veronica, Lipka, Daniel B., Zapatka, Marc, Hanf, Dorothea, List, Catrin, Allgäuer, Michael, Penzel, Roland, Rüter, Gina, Jelas, Ivan, Hamacher, Rainer, Falkenhorst, Johanna, Wagner, Sebastian, Brandts, Christian H., Boerries, Melanie, Illert, Anna L., Metzeler, Klaus H., Westphalen, C. Benedikt, Desuki, Alexander, Kindler, Thomas, Folprecht, Gunnar, Weichert, Wilko, Brors, Benedikt, Stenzinger, Albrecht, Schröck, Evelin, Hübschmann, Daniel, Horak, Peter, Heining, Christoph, Fröhling, Stefan, Glimm, Hanno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346116/
https://www.ncbi.nlm.nih.gov/pubmed/35918329
http://dx.doi.org/10.1038/s41467-022-31866-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346116/
https://www.ncbi.nlm.nih.gov/pubmed/35918329
http://dx.doi.org/10.1038/s41467-022-31866-4

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