Segregated cation flux by TPC2 biases Ca(2+) signaling through lysosomes

Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that drive endocytic ion flux and membrane traffic. Here we show that TPC2 can differentially regulate its cation permeability when co-activated by its endogenous ligands, NAADP and PI(3,5)P(2). Whereas NAADP ren...

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Detalles Bibliográficos
Autores principales: Yuan, Yu, Jaślan, Dawid, Rahman, Taufiq, Bolsover, Stephen R., Arige, Vikas, Wagner, Larry E., Abrahamian, Carla, Tang, Rachel, Keller, Marco, Hartmann, Jonas, Rosato, Anna S., Weiden, Eva-Maria, Bracher, Franz, Yule, David I., Grimm, Christian, Patel, Sandip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346130/
https://www.ncbi.nlm.nih.gov/pubmed/35918320
http://dx.doi.org/10.1038/s41467-022-31959-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346130/
https://www.ncbi.nlm.nih.gov/pubmed/35918320
http://dx.doi.org/10.1038/s41467-022-31959-0

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