PPARα alleviates iron overload‐induced ferroptosis in mouse liver

Ferroptosis is an iron‐dependent form of non‐apoptotic cell death implicated in liver, brain, kidney, and heart pathology. How ferroptosis is regulated remains poorly understood. Here, we show that PPARα suppresses ferroptosis by promoting the expression of glutathione peroxidase 4 (Gpx4) and by inh...

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Detalles Bibliográficos
Autores principales: Xing, Guowei, Meng, Lihua, Cao, Shiyao, Liu, Shenghui, Wu, Jiayan, Li, Qian, Huang, Wendong, Zhang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346473/
https://www.ncbi.nlm.nih.gov/pubmed/35703725
http://dx.doi.org/10.15252/embr.202052280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346473/
https://www.ncbi.nlm.nih.gov/pubmed/35703725
http://dx.doi.org/10.15252/embr.202052280

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