Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

Ubiquitin‐binding shuttle UBQLN2 mediates crosstalk between proteasomal degradation and autophagy, likely via interactions with K48‐ and K63‐linked polyubiquitin chains, respectively. UBQLN2 comprises self‐associating regions that drive its homotypic liquid–liquid phase separation (LLPS). Specific i...

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Detalles Bibliográficos
Autores principales: Dao, Thuy P, Yang, Yiran, Presti, Maria F, Cosgrove, Michael S, Hopkins, Jesse B, Ma, Weikang, Loh, Stewart N, Castañeda, Carlos A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346500/
https://www.ncbi.nlm.nih.gov/pubmed/35762418
http://dx.doi.org/10.15252/embr.202255056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346500/
https://www.ncbi.nlm.nih.gov/pubmed/35762418
http://dx.doi.org/10.15252/embr.202255056

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