Cargando…

Mechanistic insights into enhancement or inhibition of phase separation by different polyubiquitin chains

Ubiquitin‐binding shuttle UBQLN2 mediates crosstalk between proteasomal degradation and autophagy, likely via interactions with K48‐ and K63‐linked polyubiquitin chains, respectively. UBQLN2 comprises self‐associating regions that drive its homotypic liquid–liquid phase separation (LLPS). Specific i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dao, Thuy P, Yang, Yiran, Presti, Maria F, Cosgrove, Michael S, Hopkins, Jesse B, Ma, Weikang, Loh, Stewart N, Castañeda, Carlos A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346500/ https://www.ncbi.nlm.nih.gov/pubmed/35762418 http://dx.doi.org/10.15252/embr.202255056

Ejemplares similares

Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
por: Sun, Daxiao, et al.
Publicado: (2018)

Liquid Phase Separation of NEMO Induced by Polyubiquitin Chains Activates NF-κB
por: Du, Mingjian, et al.
Publicado: (2022)

Recent advances in polyubiquitin chain recognition
por: Wu, Hao, et al.
Publicado: (2010)

The HLA-DRα Chain Is Modified by Polyubiquitination
por: Lapaque, Nicolas, et al.
Publicado: (2009)

Mechanisms of Generating Polyubiquitin Chains of Different Topology
por: Suryadinata, Randy, et al.
Publicado: (2014)

A Highly Efficient Synthesis of Polyubiquitin Chains
por: Qu, Qian, et al.
Publicado: (2018)

Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains
por: Xia, Zong-Ping, et al.
Publicado: (2009)

Structure and recognition of polyubiquitin chains of different lengths and linkage
por: Fushman, David, et al.
Publicado: (2011)

The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
por: Morimoto, Daichi, et al.
Publicado: (2015)

Genetic analysis reveals functions of atypical polyubiquitin chains
por: Meza Gutierrez, Fernando, et al.
Publicado: (2018)

A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria
por: Riley, Brigit E., et al.
Publicado: (2015)

Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
por: Takahashi, Tomio S., et al.
Publicado: (2018)

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation
por: Nguyen, Lan K., et al.
Publicado: (2014)

Ion Mobility Mass Spectrometry Unveils Global Protein Conformations in Response to Conditions that Promote and Reverse Liquid–Liquid Phase Separation
por: Robb, Christina Glen, et al.
Publicado: (2023)

Mechanistic Insights into the Phase Separation Behavior and Pathway‐Directed Information Exchange in all‐DNA Droplets
por: Liu, Wei, et al.
Publicado: (2022)

The dynamics of linear polyubiquitin
por: Jussupow, Alexander, et al.
Publicado: (2020)

The Proteasome Distinguishes between Heterotypic and Homotypic Lysine-11-Linked Polyubiquitin Chains
por: Grice, Guinevere L., et al.
Publicado: (2015)

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12
por: Riedinger, Christiane, et al.
Publicado: (2010)

PolyUbiquitin Chain Linkage Topology Selects the Functions from the Underlying Binding Landscape
por: Wang, Yong, et al.
Publicado: (2014)

Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes
por: Park, Sungjin, et al.
Publicado: (2015)

The Dark Side of EGFP: Defective Polyubiquitination
por: Baens, Mathijs, et al.
Publicado: (2006)

Regulation of PCNA polyubiquitination in human cells
por: Brun, Jan, et al.
Publicado: (2010)

Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains
por: Boname, Jessica M, et al.
Publicado: (2010)

The Ubiquitin Interacting Motif-Like Domain of Met4 Selectively Binds K48 Polyubiquitin Chains
por: Villamil, Mark, et al.
Publicado: (2021)

Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
por: Wegmann, Sabrina, et al.
Publicado: (2022)

Preparation of site-specifically fluorophore-labeled polyubiquitin chains for FRET studies of Cdc48 substrate processing
por: Williams, Cameron, et al.
Publicado: (2023)

Melatonin in Endometriosis: Mechanistic Understanding and Clinical Insight
por: Li, Yiran, et al.
Publicado: (2022)

Top-Down 193-nm Ultraviolet Photodissociation Mass Spectrometry for Simultaneous Determination of Polyubiquitin Chain Length and Topology
por: Cannon, Joe R., et al.
Publicado: (2015)

A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors
por: Takahashi, Hirotaka, et al.
Publicado: (2020)

Functional Characterization of Potato UBC13-UEV1s Genes Required for Ubiquitin Lys63 Chain to Polyubiquitination
por: Liu, Weigang, et al.
Publicado: (2023)

Hydrogen-Deuterium Exchange Profiles of Polyubiquitin Fibrils
por: Morimoto, Daichi, et al.
Publicado: (2018)

Protein phase separation: new insights into cell division: Phase separation in cell division
por: Zheng, Hongdan, et al.
Publicado: (2023)

Mechanistic Insights into Two-Phase Radical C–H Arylations
por: Baxter, Ryan D., et al.
Publicado: (2015)

Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates
por: Masuda, Yuji, et al.
Publicado: (2019)

Protein Phase Separation: New Insights into Carcinogenesis
por: Luo, Yan, et al.
Publicado: (2022)

Polyubiquitination inhibition of estrogen receptor alpha and its implications in breast cancer
por: Tecalco-Cruz, Angeles C, et al.
Publicado: (2018)

Chain Formation and Phase Separation in Ferrofluids: The Influence on Viscous Properties
por: Ivanov, Alexey O., et al.
Publicado: (2020)

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity
por: Nanda, Sambit K., et al.
Publicado: (2011)

Drosophila Morgue Associates with SkpA and Polyubiquitin In Vivo
por: Zhou, Ying, et al.
Publicado: (2013)

The role of K63‐linked polyubiquitination in cardiac hypertrophy
por: Yan, Kaowen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ne9bqps38n44uk5chtf8702t4q