TP53 copy number and protein expression inform mutation status across risk categories in acute myeloid leukemia

Mutant TP53 is an adverse risk factor in acute myeloid leukemia (AML), but large-scale integrated genomic-proteomic analyses of TP53 alterations in patients with AML remain limited. We analyzed TP53 mutational status, copy number (CN), and protein expression data in AML (N = 528) and provide a compi...

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Detalles Bibliográficos
Autores principales: Tashakori, Mehrnoosh, Kadia, Tapan, Loghavi, Sanam, Daver, Naval, Kanagal-Shamanna, Rashmi, Pierce, Sherry, Sui, Dawen, Wei, Peng, Khodakarami, Farnoosh, Tang, Zhenya, Routbort, Mark, Bivins, Carol A., Jabbour, Elias J., Medeiros, L. Jeffrey, Bhalla, Kapil, Kantarjian, Hagop M., Ravandi, Farhad, Khoury, Joseph D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346958/
https://www.ncbi.nlm.nih.gov/pubmed/35390143
http://dx.doi.org/10.1182/blood.2021013983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9346958/
https://www.ncbi.nlm.nih.gov/pubmed/35390143
http://dx.doi.org/10.1182/blood.2021013983

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