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Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts
We present an efficient and easy synthesis method for incorporating organocatalytic moieties into Zr-metal organic frameworks (Zr-MOFs). The catalytic activity and selectivity of the new chiral catalysts were improved by adjusting the aperture of the MOF cavities. The hole size of the Zr-MOF was mod...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347210/ https://www.ncbi.nlm.nih.gov/pubmed/35975053 http://dx.doi.org/10.1039/d2ra03747e |
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author | Zhu, Junfeng Meng, Xiaorong Liu, Wen Qi, Yabing Jin, Siyi Huo, Shanshan |
author_facet | Zhu, Junfeng Meng, Xiaorong Liu, Wen Qi, Yabing Jin, Siyi Huo, Shanshan |
author_sort | Zhu, Junfeng |
collection | PubMed |
description | We present an efficient and easy synthesis method for incorporating organocatalytic moieties into Zr-metal organic frameworks (Zr-MOFs). The catalytic activity and selectivity of the new chiral catalysts were improved by adjusting the aperture of the MOF cavities. The hole size of the Zr-MOF was modulated by adding acid and replacing bridge ligands during synthesis. The difunctional chiral units of amino acid–thiourea are anchored onto the Zr-MOF by a mild synthesis method from an isothiocyanate intermediate which could effectively avoid the racemization of chiral moieties in the synthesis process. By means of specific surface area measurement (BET), scanning electron microscopy (SEM) and powder X-ray Diffraction (PXRD), it was confirmed that Zr-MOFs with different pore sizes were synthesized without breaking the basic octahedral structure of the MOF. Finally, good yields (up to 83%) and ee values (up to 73%) were achieved with the new heterogeneous catalysts in 48 hours for the aldol reaction of 4-nitrobenzaldehyde with acetone. By contrast, using the catalyst support without modulating the synthesis, the yield (30%) and the ee-value (26%) were both low. Experiments have confirmed the important influence on the reaction selectivity of providing a suitable reaction environment by controlling the aperture of MOF cavities. |
format | Online Article Text |
id | pubmed-9347210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-93472102022-08-15 Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts Zhu, Junfeng Meng, Xiaorong Liu, Wen Qi, Yabing Jin, Siyi Huo, Shanshan RSC Adv Chemistry We present an efficient and easy synthesis method for incorporating organocatalytic moieties into Zr-metal organic frameworks (Zr-MOFs). The catalytic activity and selectivity of the new chiral catalysts were improved by adjusting the aperture of the MOF cavities. The hole size of the Zr-MOF was modulated by adding acid and replacing bridge ligands during synthesis. The difunctional chiral units of amino acid–thiourea are anchored onto the Zr-MOF by a mild synthesis method from an isothiocyanate intermediate which could effectively avoid the racemization of chiral moieties in the synthesis process. By means of specific surface area measurement (BET), scanning electron microscopy (SEM) and powder X-ray Diffraction (PXRD), it was confirmed that Zr-MOFs with different pore sizes were synthesized without breaking the basic octahedral structure of the MOF. Finally, good yields (up to 83%) and ee values (up to 73%) were achieved with the new heterogeneous catalysts in 48 hours for the aldol reaction of 4-nitrobenzaldehyde with acetone. By contrast, using the catalyst support without modulating the synthesis, the yield (30%) and the ee-value (26%) were both low. Experiments have confirmed the important influence on the reaction selectivity of providing a suitable reaction environment by controlling the aperture of MOF cavities. The Royal Society of Chemistry 2022-08-03 /pmc/articles/PMC9347210/ /pubmed/35975053 http://dx.doi.org/10.1039/d2ra03747e Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/ |
spellingShingle | Chemistry Zhu, Junfeng Meng, Xiaorong Liu, Wen Qi, Yabing Jin, Siyi Huo, Shanshan Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title | Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title_full | Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title_fullStr | Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title_full_unstemmed | Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title_short | Regulated synthesis of Zr-metal–organic frameworks with variable hole size and its influence on the performance of novel MOF-based heterogeneous amino acid–thiourea catalysts |
title_sort | regulated synthesis of zr-metal–organic frameworks with variable hole size and its influence on the performance of novel mof-based heterogeneous amino acid–thiourea catalysts |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347210/ https://www.ncbi.nlm.nih.gov/pubmed/35975053 http://dx.doi.org/10.1039/d2ra03747e |
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