Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase

Homologues of natural epigenetic pyrimidine nucleosides and nucleotides were designed and synthesized. They included 5-ethyl-, 5-propyl-, 5-(1-hydroxyethyl)-, 5-(1-hydroxypropyl)- and 5-acetyl- and 5-propionylcytosine and -uracil 2′-deoxyribonucleosides and their corresponding 5′-O-triphosphates (dN...

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Detalles Bibliográficos
Autores principales: Gracias, Filip, Ruiz-Larrabeiti, Olatz, Vaňková Hausnerová, Viola, Pohl, Radek, Klepetářová, Blanka, Sýkorová, Veronika, Krásný, Libor, Hocek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347353/
https://www.ncbi.nlm.nih.gov/pubmed/35975001
http://dx.doi.org/10.1039/d2cb00133k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9347353/
https://www.ncbi.nlm.nih.gov/pubmed/35975001
http://dx.doi.org/10.1039/d2cb00133k

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