Targeting 3D chromosomal architecture at the RANK loci to suppress myeloma-driven osteoclastogenesis

Bone disease represents a major cause of morbidity and mortality in Multiple Myeloma (MM); primarily driven by osteoclasts whose differentiation is dependent on expression of RANKL by MM cells. Notably, costimulation by ITAM containing receptors (i.e., FcγR) can also play a crucial role in osteoclas...

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Detalles Bibliográficos
Autores principales: Thümmler, Katja, Williams, Mark TS, Kitson, Susan, Sood, Shatakshi, Akbar, Moeed, Cole, John J, Hunter, Ewan, Soutar, Richard, Goodyear, Carl S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348127/
https://www.ncbi.nlm.nih.gov/pubmed/35936985
http://dx.doi.org/10.1080/2162402X.2022.2104070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348127/
https://www.ncbi.nlm.nih.gov/pubmed/35936985
http://dx.doi.org/10.1080/2162402X.2022.2104070

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