The SKP2‐p27 axis defines susceptibility to cell death upon CHK1 inhibition

Checkpoint kinase 1 (CHK1; encoded by CHEK1) is an essential gene that monitors DNA replication fidelity and prevents mitotic entry in the presence of under‐replicated DNA or exogenous DNA damage. Cancer cells deficient in p53 tumor suppressor function reportedly develop a strong dependency on CHK1...

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Detalles Bibliográficos
Autores principales: Lohmüller, Michael, Roeck, Bernhard F., Szabo, Tamas G., Schapfl, Marina A., Pegka, Fragka, Herzog, Sebastian, Villunger, Andreas, Schuler, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348596/
https://www.ncbi.nlm.nih.gov/pubmed/35673965
http://dx.doi.org/10.1002/1878-0261.13264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348596/
https://www.ncbi.nlm.nih.gov/pubmed/35673965
http://dx.doi.org/10.1002/1878-0261.13264

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