NNK from tobacco smoking enhances pancreatic cancer cell stemness and chemoresistance by creating a β2AR‐Akt feedback loop that activates autophagy

Low responsiveness to chemotherapy is an important cause of poor prognosis in pancreatic cancer. Smoking is a high‐risk factor for pancreatic cancer and cancer resistance to gemcitabine; however, the underlying mechanisms remain unclear. 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) is the ma...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Zhang, Weifan, Liu, Rujuan, Zhu, Zeen, Gong, Mengyuan, Wang, Qiqi, Qian, Weikun, Wu, Zheng, Ma, Qingyong, Wang, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348597/
https://www.ncbi.nlm.nih.gov/pubmed/35593085
http://dx.doi.org/10.1002/1878-0261.13230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348597/
https://www.ncbi.nlm.nih.gov/pubmed/35593085
http://dx.doi.org/10.1002/1878-0261.13230

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