RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC), which constitutes the initiating event in t...

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Detalles Bibliográficos
Autores principales: Otto, Christoph, Kastner, Carolin, Schmidt, Stefanie, Uttinger, Konstantin, Baluapuri, Apoorva, Denk, Sarah, Rosenfeldt, Mathias T., Rosenwald, Andreas, Roehrig, Florian, Ade, Carsten P., Schuelein‐Voelk, Christina, Diefenbacher, Markus E., Germer, Christoph‐Thomas, Wolf, Elmar, Eilers, Martin, Wiegering, Armin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348601/
https://www.ncbi.nlm.nih.gov/pubmed/35673898
http://dx.doi.org/10.1002/1878-0261.13265

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348601/
https://www.ncbi.nlm.nih.gov/pubmed/35673898
http://dx.doi.org/10.1002/1878-0261.13265

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