Human iPSC-derived astrocytes generated from donors with globoid cell leukodystrophy display phenotypes associated with disease

Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine. While oligodendrocytes have been extensively studied due to their...

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Detalles Bibliográficos
Autores principales: Lieberman, Richard, Cortes, Leslie K., Gao, Grace, Park, Hyejung, Wang, Bing, Jones, Patrick L., Hunter, R. Bridge, Leonard, John P., Barker, Robert H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348679/
https://www.ncbi.nlm.nih.gov/pubmed/35921286
http://dx.doi.org/10.1371/journal.pone.0271360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348679/
https://www.ncbi.nlm.nih.gov/pubmed/35921286
http://dx.doi.org/10.1371/journal.pone.0271360

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