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Chemoradiation-induced alteration of programmed death-ligand 1, CD8+ tumor-infiltrating lymphocytes and mucin expression in rectal cancer

Introduction: DNA damage and resulting neoantigen formation is considered a mechanism for synergy between radiotherapy and PD-1/PD-L1 pathway inhibition to induce antitumor immune response. We investigated neoadjuvant chemoradiotherapy (nCRT)-induced changes in CD8+ tumor infiltrating lymphocyte, PD...

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Detalles Bibliográficos
Autores principales: Baretti, Marina, Zhu, Qingfeng, Fu, Wei, Meyer, Jeffrey, Wang, Hao, Anders, Robert A., Azad, Nilofer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348692/
https://www.ncbi.nlm.nih.gov/pubmed/35937503
http://dx.doi.org/10.18632/oncotarget.28255