A novel mechanism of regulation of the oncogenic transcription factor GLI3 by toll-like receptor signaling

The transcription factor GLI3 is a member of the GLI family and has been shown to be regulated by canonical hedgehog (HH) signaling through smoothened (SMO). Little is known about SMO-independent regulation of GLI3. Here, we identify TLR signaling as a novel pathway regulating GLI3 expression. We sh...

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Detalles Bibliográficos
Autores principales: Matissek, Stephan J., Karbalivand, Mona, Han, Weiguo, Boutilier, Ava, Yzar-Garcia, Estefania, Kehoe, Laura L., Gardner, Devin Storm, Hage, Adam, Fleck, Krista, Jeffers, Vicki, Rajsbaum, Ricardo, Elsawa, Sherine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2022
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348707/
https://www.ncbi.nlm.nih.gov/pubmed/35937499
http://dx.doi.org/10.18632/oncotarget.28261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348707/
https://www.ncbi.nlm.nih.gov/pubmed/35937499
http://dx.doi.org/10.18632/oncotarget.28261

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