Single-cell analysis of a high-grade serous ovarian cancer cell line reveals transcriptomic changes and cell subpopulations sensitive to epigenetic combination treatment

Ovarian cancer (OC) is a lethal gynecological malignancy with a five-year survival rate of only 46%. Development of resistance to platinum-based chemotherapy is a common cause of high mortality rates among OC patients. Tumor and transcriptomic heterogeneity are drivers of platinum resistance in OC....

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Detalles Bibliográficos
Autores principales: Sriramkumar, Shruthi, Metcalfe, Tara X., Lai, Tim, Zong, Xingyue, Fang, Fang, O’Hagan, Heather M., Nephew, Kenneth P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348737/
https://www.ncbi.nlm.nih.gov/pubmed/35921335
http://dx.doi.org/10.1371/journal.pone.0271584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348737/
https://www.ncbi.nlm.nih.gov/pubmed/35921335
http://dx.doi.org/10.1371/journal.pone.0271584

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