Conserved conformational dynamics determine enzyme activity

Homologous enzymes often exhibit different catalytic rates despite a fully conserved active site. The canonical view is that an enzyme sequence defines its structure and function and, more recently, that intrinsic protein dynamics at different time scales enable and/or promote catalytic activity. He...

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Detalles Bibliográficos
Autores principales: Torgeson, Kristiane R., Clarkson, Michael W., Granata, Daniele, Lindorff-Larsen, Kresten, Page, Rebecca, Peti, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348788/
https://www.ncbi.nlm.nih.gov/pubmed/35921420
http://dx.doi.org/10.1126/sciadv.abo5546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348788/
https://www.ncbi.nlm.nih.gov/pubmed/35921420
http://dx.doi.org/10.1126/sciadv.abo5546

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